The Role of IL-17A in the Pathogenesis of Ankylosing Spondylitis

Abstract

The etiology of Ankylosing Spondylitis (AS) is still unclear, however recent studies discover that several cytokines play an important role in progression of AS including interleukin-17. As a pro inflammatory cytokine IL-17 also facilitate production of other cytokines. The IL-17 pathways is a promising targeted therapy for managing AS.